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Beilstein J. Org. Chem. 2013, 9, 260–264, doi:10.3762/bjoc.9.31
Graphical Abstract
Figure 1: p21 determines the fate of DNA-damaged [13] cells.
Figure 2: Retrosynthetic analysis of LLW62 (1) from acid 7 (A) or aldehyde 11 (B).
Scheme 1: Attempted synthesis of aldehyde 4 from nitrile 6.
Scheme 2: (A) Synthesis of 4 from acid 7 and (B) attempted β-amino acid-forming 3CRs.
Scheme 3: Synthesis of LLW62 by using an early stage 3CR.